Neoadjuvant Furmonertinib and Cisplatin/Pemetrexed as in EGFR Mutated Stage IIIA-IIIB Resectable NSCLC (FORESEE)
- Conditions
- Non-small Cell Lung Cancer
- Interventions
- Drug: Furmonertinib+cisplating/pemetrexed
- Registration Number
- NCT05430802
- Lead Sponsor
- Tang-Du Hospital
- Brief Summary
In this open-label, single-arm, phase 2 study, 40 eligible patients with EGFR mutated stage IIIA-IIIB resectable NSCLC will be recruited to receive furmonertinib for 9 weeks combined with cisplatin/pemetrexed for 3 cycles (21 d/cycle) as neoadjuvant therapy before radical surgery. Radiological and pathological evaluations will be performed before and after the neoadjuvant therapy to assess the efficacy of treatment. Adverse events during neoadjuvant therapy, disease and survival status will also be collected in the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
- With written informed consent before any study procedure
- Histology or cytology diagnose of non-small cell lung cancer within 60 days
- Stage IIIA/IIIB, with resectable lesion(s) by radiology
- EGFR mutation positive (exon 19 deletions or exon 21 L858R, with or without other EGFR mutations)
- Without prior anti-tumor treatment
- With at least one measurable lesions (The longest axis ≥10mm)
- ECOG performance status 0-1
- Using adequate and effective contraception, women should refrain from breastfeeding and have a negative pregnancy test prior to the first administration of the study drug if within during child-bearing age
- EGFR Exon 20 insertions positive
- Mixed with small cell cancer, or other mixed types of lung cancer
- Any prior anti-tumor treatment
- Major surgery within 4 weeks before enrolment
- Women with pregnancy or breastfeeding
- Use of strong CYP3A4 inhibitors within 7 days or strong CYP3A4 inducers within 21 days before enrolment; use of traditional Chinese medicine with anti-tumor effect within 21 days before enrolment
- With history of other malignancy except for radical resected tumors without recurrence for 5 years or more
- With severe or uncontrolled systemic disease such as uncontrolled hypertention, diabetes mellitus, chronic heart failure, unstable angina, myocardial infarction within 1 year, active hemorrhage, active HBV/HCV/HIV or other infections requiring infusion treatment
- Severe gastrointestinal diseases which may affect the intake and absorption of study drug
- Prolongation of ECG QTc or with relative risk factors
- History of interstitial lung disease or with relative risk factors
- Inadequate organ function of hematology, liver and kidney
- Allergic to study drugs or any component
- Poor adherence or other situation judged by investigator
- Patients who had participated other clinical studies of tumors
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Furmonertinib plus cisplatin/pemetrexed Furmonertinib+cisplating/pemetrexed furmonertinib 80mg/d for 9 weeks and cisplatin 75mg/m2 d1 iv + pemetrexed 500mg/m2 d1 iv at 21 day cycles for 3 cycles
- Primary Outcome Measures
Name Time Method Objective response rate Approximately 9 weeks following the first dose of study drug The proportion of patients with complete response or partial response
- Secondary Outcome Measures
Name Time Method Major pathological response rate Approximately 12 weeks following the first dose of study drug The proportion of patients with pathological response in the resected tumor
Pathological complete response rate Approximately 12 weeks following the first dose of study drug The proportion of patients with pathological response rate in the resected tumor
R0 resection rate Approximately 12 weeks following the first dose of study drugs The proportion of patients with R0 resection
Disease free survival Approximately 3 years following the first dose of study drugs The time from enrolment to disease recurrence or death, which ever comes first
Overall survival Approximately 5 years following the first dose of study drugs The time from enrolment to death of any reason
Pathological downstaging of lymph node rate Approximately 12 weeks following the first dose of study drugs The proportion of patients with pathological downstaging of lymph node rate
Trial Locations
- Locations (1)
Tangdu Hospital
🇨🇳Xi'an, Shannxi, China