Clinical Database and Biobank of Pulmonary Ground Glass Nodules Patients With Family History, a Prospective Cohort Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- The prevalence of family aggregation of pulmonary ground glass nodule.
研究概览
简要总结
The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying genetic mechanism via the biobank.
详细描述
In recent years, with the development of low-dose chest CT screening, more and more ground glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the early-stage lung adenocarcinoma patients with lung cancer family history have been emerging increasing in recent years in East Asian.
This prospective cohort study, with both a cross-sectional and a longitudinal part, will include patients with pulmonary ground glass nodule, which were proven malignant disease.
All participants will be asked to complete questionnaire to build the clinical database of GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will be collected as a specific biobank. And the blood samples of other family members of participants will be collected, with their consent and knowledge.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with informed consent;
- •patients with pulmonary ground glass nodule.
- •pathological proved early stage lung cancer.
排除标准
- •1.not included in the inclusion criteria
结局指标
主要结局
The prevalence of family aggregation of pulmonary ground glass nodule.
时间窗: 1 week
To investigate the aggregation of pulmonary ground glass nodule among first-degree relatives of participants via the questionnaire.
次要结局
- Susceptibility genetic events related to the family aggregation of ground glass nodules.(1 month)
研究者
Wen-zhao ZHONG
Porfessor
Guangdong Provincial People's Hospital