Higher hemoglobin trigger threshold for red blood cell transfusion during sepsis/septic shock resuscitation associated with better sepsis outcome.

Completed

• Conditions: Sepsis and septic shock patients; Sepsis; Septic shock; RBC transfusion; Hemoglobin level; Restrictive blood transfusion; Liberal blood transfusion

• Registration Number: TCTR20231003003
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

the 28-day mortality was 51.2% in liberal group, comparing with 59.2% in restrictive group (Odd ratio [OR] 0.88; 95% confidence interval [CI] 0.79-0.98; P 0.031)

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-12-28
• Study Start: 2023-10-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 806

Inclusion Criteria

1. Patients who were diagnosed with sepsis and septic shock, as indicated by an ICD-10 code
2. Adult patients (at least 18 years old)
3. Admitted between between 1st March 2018 to 31st January 2022
4. Met the criteria for sepsis or septic shock diagnosis according to the Surviving Sepsis Campaign 2016
5. Received PRC transfusion within 3 days after sepsis or septic shock diagnosis

Exclusion Criteria

1. Clinically important bleeding (which means overt bleeding accompanied by a decrease in systolic blood pressure of more than 20 mmHg, an increase in pulse rate of more than 20 beats per minute, or a drop in hemoglobin levels of more than 2 g/dL)
2. Acute coronary syndrome
3. Overt gastrointestinal bleeding
4. Immediate post-operative patients

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-day mortality 28 days after sepsis/septic shock was diagnosed Death or survive

Secondary Outcome Measures

Name	Time	Method
ength of hospital stay Duration of hospital admission Days,Acute kidney injury From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Pulmonary edema From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,ARDS From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Cardiac arrest From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred,Bowel ischemia From sepsis/septic shock was diagnosed until hospital discharge or death Occurred or not occurred