The Effect Of The Presence Of Endometriomas On Ovarian Reserve
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Change in Serum Anti- mullerian hormone (AMH) level
研究概览
简要总结
Prior studies have shown surgical excision of endometriomas are associated with a decline in ovarian reserve as assessed by serum anti-Mullerian Hormone (AMH) levels. However, the natural history of serum AMH levels in the presence of untreated endometriomas are unknown. Purpose of this study is to determine whether the presence of endometriomas cause a faster decline in serum AMH levels than in healthy women over a six months period.
详细描述
The study is a prospective cohort study. Women diagnosed with endometriomas by transvaginal or transabdominal ultrasound or MRI will be recruited from a tertiary care endometriosis clinic. Age matched healthy controls will be recruited from the staff of the same hospital. A priorly published historical group of women who underwent endometrioma excision will be a second comparator.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Reproductive age
- •Endometrioma without indication for surgery or treatment with combined contraceptive, progestin or other hormonal intervention.
排除标准
- •Menstrual cycle irregularity
- •Polycystic ovarian syndrome
- •Women who were pregnant or contemplating pregnancy in the next six months
- •History of ovarian surgery
- •Using medication which could affect ovarian function during six months before recruitment
- •Indication for surgical excision
结局指标
主要结局
Change in Serum Anti- mullerian hormone (AMH) level
时间窗: at recruitment and six months later
次要结局
未报告次要终点
研究者
GÜRKAN UNCU,PROF. MD
prof.md
Uludag University