Predictors of Failure of Non-invasive Ventilation and High Flow Nasal Cannula

Not yet recruiting

• Conditions: Acute Respiratory Failure Patients on NIV and HFNC

• Registration Number: NCT05864898
• Lead Sponsor: Assiut University

Brief Summary

Comparison between some predictors of failure of non-invasive ventilation and high flow nasal cannula.

Detailed Description

Delayed intubation after NIV / HFNC failure is associated with high mortality rate in acute respiratory failure patients.

There are Many factors to predict early failure but World still searching for new factors and comparing between each ;in order to eatablish best one that achieve the least mortality rate.

Little studies about effiecacy of HACOR Score as a predictor of failure in HFNC patients.

Little studies about effiecacy of ROX Index as a predictor of failure in NIV ventilating patients.

Study Timeline

• Study First Submitted: 2023-03-22
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-16
• Last Update Submitted: 2023-05-16
• Study First Posted: 2023-05-18
• Last Update Posted: 2023-05-18
• Study Start: 2023-07-01
• Primary Completion: 2024-04-01
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Acute respiratory failure patients who need ventilatory Support either NIV or HFNC due to :

1. RR > 25 cycle / min
2. using accessory muscles and paradoxical breath.
3. PaO2 / FiO2 ratio < 300

Exclusion Criteria

1. Absolute indication for intubation like coma, haemodynamically unstable... etc
2. Contr-indication of NIV like untreated Pneumothorax.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine Golden time for intubation	1 year	Determine best time for intubation according to some predictors of failure of NIV and HFNC