Cortical activation in pre-lingually deaf adults, with and without a cochlear implant

Conditions: sensorineural hearing loss
severe hearing loss and deafness
10013995
10019243

Registration Number: NL-OMON31996

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 28

Inclusion Criteria

1. Adults (18 years of age or older)
2. Right handed
3. Normal hearing group: having a pure-tone air conduction thresholds <= 15 dB HL
4. Unilaterally implanted pre-lingual deaf group: total or profound sensorineural hearing loss during the first 1.5 years of life
a. Implanted group with good results: consonant-vowel-consonant (CVC) score > 50% (open-set monosyllable lists according to the *Nederlandse Vereniging van Audiologie* (NVA)).
b. Implanted group with poor results: consonant-vowel-consonant (CVC) score < 50% (open-set, monosyllable lists according to NVA).
5. Prelingual deaf CI candidates: profound sensorineural hearing loss during the first 1.5 years of life, Pure tone average > 90 dB and < 10% open-set speech recognition (monosyllable lists, according to NVA).

Exclusion Criteria

1.Pregnancy/breastfeeding
2.Diabetis Mellitus (type I and II)
3.Claustrophobic

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The cerebral glucose metabolism (and hence the cortical activity) is measured<br /><br>by the regional [18F]-FDG uptake ([18F]-FDG is an analogue for glucose).<br /><br><br /><br>To study the auditory neural processing with ERPs, the amplitude, latency and<br /><br>morphology of the N1, P2 and P300 responses are evaluated.</p><br>

Secondary Outcome Measures