Oxygen therapy and myocardial ischaemia during exercise testing

Phase 4

Recruiting

• Conditions: Myocardial ischaemia; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12607000202460
• Lead Sponsor: Dr Mark Simmonds

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-04-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Inducible ischaemia on ETT with chest pain.

Exclusion Criteria

Abnormal resting electrocardiogram (ECG)ST-elevation during the ETTGlobal ischaemia during the ETT suggesting a possible left main stem lesionArrythmia during the ETTUnstable angina (daily episodes at rest)Left bundle branch block developing during the ETTCongestive heart failureSevere hypertension (systolic >200mmHg)Chronic obstructive respiratory disease or other respiratory disease with oxygen saturations measured at <92% on room airPatients who do not develop chest pain despite evidence of inducible ischaemiaUnstable gaitPatients with contraindication to aspirin, metoprolol or simvastatin.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to onset of chest pain and inducible ischaemia [Monitored continuously as per normal ETT.]

Secondary Outcome Measures

Name	Time	Method
Magnitude of ST depression at peak exercise. The ST segment represents the period from the end of ventricular depolarization to the beginning of ventricular repolarization.[Measured at the end of ETT.];Number of leads showing ST depression. [Measured at the end of ETT.];Blood pressure and heart rate changes.[ Measured every 3 minutes as per standard ETT.]