Optimal Attained LDL-Cholesterol Levels in Patients Who Achieved ≥50% LDL Reduction After PCI
Completed
- Conditions
- Coronary Artery DiseaseHyperlipidemias
- Interventions
- Drug: LDL reduction therapy
- Registration Number
- NCT06338956
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
For the management of low-density lipoprotein-cholesterol (LDL-C), some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in LDL-C levels. High-intensity or maximally tolerated intensity can be maintained without a target goal. However, the European guideline recommends less than 55 mg/dL of LDL-C after PCI.
- Detailed Description
To investigate the Optimal Attained LDL-C Levels in Patients Who Achieved ≥50% LDL-C Reduction After PCI.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 135877
Inclusion Criteria
- Patients receiving PCI with health check up before and after PCI within 3 years
Exclusion Criteria
- Patients receiving statin before PCI
- Patients with liver cirrhosis
- Patients with cancer
- Patients without prescription of statin
- Patients with LDL-C <55 mg/dL before PCI
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description >=50% LDL-C reduction LDL reduction therapy LDL-C reduction \>=50% Further divided by LDL \<55mg/dL 55\< LDL \< 70 mg/dL LDL \> 70 mg/dL <50% LDL-C reduction LDL reduction therapy LDL-C reduction \<50%
- Primary Outcome Measures
Name Time Method MACCE 10 years after PCI major adverse cardiac and cerebrovascular events
- Secondary Outcome Measures
Name Time Method Cardiovascular death 10 years after PCI death from cardiovascular cause
Repeat revascularization 10 years after PCI additional PCI or CABG
Spontaneous myocardial infarction 10 years after PCI MI with hospitalziation
Ischemic stroke 10 years after PCI Stoke from ischemic cause
Trial Locations
- Locations (1)
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of