Comparison of the efficacy of topiramate and sodium valporate in migraine headaches
Phase 2
- Conditions
- Classic migraine.Classic(with aura)migraine
- Registration Number
- IRCT201011025076N1
- Lead Sponsor
- Vice-chancellor for research, Ahvaz Jondishapour University of Medical Sciences and Health Services
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
Patient’s age between 20 and 45 years, discontinuation of other prophylactic drugs one month prior to study, interval between attacks more than 48 hours Exclusion criteria: pregnancy and breast feeding, non-migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries) minimal age:20 maximal age:45 sex:female
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Headache severity. Timepoint: On each episode of headache. Method of measurement: The patient registers the severity of her headaches in daily notes according to VAS(FROM 1 TO 10)and these notes are registered by physician monthly.;Headache duration. Timepoint: On each headache episode. Method of measurement: The patient registers the duration of each headache episode and these data are registered by the physician monthly.;Headaches frequencies. Timepoint: Monthly. Method of measurement: According to patient's notes.;Analgesic consumption rate. Timepoint: Monthly. Method of measurement: According to patient's notes.
- Secondary Outcome Measures
Name Time Method Clinical side effects. Timepoint: Every 4 weeks. Method of measurement: According to patients daily notes.;Blood cell count & liver function test changes. Timepoint: Before and at the end of treatment course. Method of measurement: Lab tests.