Development of deuterium metabolic imaging to map body biochemistry with MRI
- Conditions
- Diabetes mellitus type 2type 2 diabetes10018424
- Registration Number
- NL-OMON56442
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
All subjects:
• Age > 40 and younger than 70 years (healthy controls and type 2 diabetes
patients matched for age; age differences of ± 5 years will be allowed)
• Sex: male
• Ability and willing to give informed consent
• Ability to follow test instructions
• Sufficient understanding of the Dutch language
Healthy control subjects:
• BMI: 20-25 kg/m2
Type 2 diabetes patients:
• Patients diagnosed with type 2 diabetes for at least 1 years
• BMI: 20-35 kg/m2
All subjects:
• Contra-indications to MRI examination according to 7T MRI screening guideline
of the UMC Utrecht
• An average alcohol consumption of >21 standard drinks per week
• Abnormal liver function (fibrosis)
Type 2 diabetes patients:
• Use of exogenous insulin
• Known causes of hepatic steatosis other than non-alcoholic fatty liver
disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are 3D DMI measurements of hepatic carbohydrate and<br /><br>lipid metabolism in the liver of healthy volunteers and type 2 diabetes<br /><br>patients. Specifically we will determine rates of glucose uptake and<br /><br>metabolism (study 1) and the fraction of de novo synthesized lipids in the<br /><br>liver lipid pool (study 2).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>