Relationship Between Serum β2-Microglobulin and Infiltration of CD8+ in the Tumor Tissue of Hodgkin's Lymphoma Patients
- Conditions
- Hodgkin Lymphoma
- Registration Number
- NCT06564259
- Lead Sponsor
- Tishreen University
- Brief Summary
In newly diagnosed Hodgkin lymphoma patients, pre-treatment Beta-2 Microglobulin (B2M) levels will be measured. A thorough baseline assessment will be performed using CT imaging, and tumor tissue samples will be collected for Immunohistochemical (IHC) analysis to quantify CD8+ cell infiltration. Patients will be closely monitored throughout their treatment, with a follow-up CT scan at the end of therapy to evaluate therapeutic response. This study aims to investigate the correlation between pre-treatment B2M levels and CD8+ immune cell infiltration in tumor tissues, assessing their potential as predictive markers for chemotherapy response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 144
- Newly diagnosed patients with Hodgkin lymphoma
- No prior history of malignancy
- Absence of primary or secondary immunodeficiencies
- Patients who have previously undergone treatment
- Patients with acute or chronic infections
- Patients with renal disorders
- Individuals with autoimmune diseases
- HIV-positive patients
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Therapeutic response 2-4 months Achieving complete remission after chemotherapy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tishreen University
🇸🇾Latakia, Syrian Arab Republic
Tishreen University🇸🇾Latakia, Syrian Arab Republic