Post-Pandemic Genomic Epidemiology of Pneumococcal Carriage Among Children and Adults in the General US Population
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 900
- 试验地点
- 1
- 主要终点
- Pneumococcal carriage prevalence and distribution of serotypes among children and adults calculated from the results of S. pneumoniae isolation using qPCR.
研究概览
简要总结
The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city. These data will allow PI to assess the post-pandemic population structure, investigate the phylogenetic relationship between isolates from children and adults, and compare pneumococcal populations across diverse geographic areas.
详细描述
The SARS-CoV-2 pandemic profoundly impacted human health directly and indirectly. As such, elucidating pre- and post-pandemic trends in the epidemiology and population genomics of human respiratory pathogens including those such as the bacteria Streptococcus pneumoniae, a human commensal and the causative agent of invasive pneumococcal disease (IPD), merits study.
Nasopharyngeal samples will be processed at the PIs Laboratory to identify S. pneumoniae. If present, the isolate will undergo bacterial whole genome sequencings and population dynamic analysis. Carriage prevalence and serotype composition will be compared to extant studies and pneumococcal genomic data will be analyzed in the context of samples from the US and abroad.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children, ages 7 to 59 months (less than 5 years)
- •Adults, ages 50 and older
- •Ability to provide informed consent (from parents for children participants)
- •ability to read and speak in English
- •Agree to comply with study procedures (complete online data questionnaire and provide a nasopharyngeal collection).
排除标准
- •Have been on an antibiotic in the last 2 weeks
- •Have a respiratory infection that would make an nasopharyngeal collection improbable
- •Have underlying developmental or chronic conditions impacting immune or respiratory function (e.g., immunocompromised, cystic fibrosis, cerebral palsy, paralysis)
- •Adults unable to consent, individuals who are not yet adults, and prisoners will be excluded from this study.
结局指标
主要结局
Pneumococcal carriage prevalence and distribution of serotypes among children and adults calculated from the results of S. pneumoniae isolation using qPCR.
时间窗: 22 months
次要结局
- Phylogenetic relationship of pneumococcal isolates collected among child and adult populations using whole-genome sequencing libraries.(22 months)
- Putative transmission networks between children and adult populations from online questionnaires.(22 months)