Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients
- Registration Number
- NCT02619526
- Lead Sponsor
- Dong-A University
- Brief Summary
Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF. However, limited data have been available on the treatment of HF with preserved ejection fraction (EF) in the elderly. No study has specifically compared the relative effectiveness of carvedilol and nebivolol in treating HF in old age patients with preserved EF.
- Detailed Description
This trial is a prospective, randomized, open-label, active controlled study designed to investigate effects of nebivolol and carvedilol on diastolic function of the left ventricle (LV) in the elderly HF patients with preserved EF.
Patients will be included in the study if they had LVEF ≥ 40%, NYHA functional class I, II or III, and clinical stability without hospital admission for HF in the preceding 3 months.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 62
- more than 70 years
- EF ≥ 40%
- contraindication to the study drug
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Nebivolol Nebivolol Nebivolol 10mg, once a day Carvedilol Carvedilol Carvedilol 25mg, twice a day
- Primary Outcome Measures
Name Time Method the ratio of transmitral E velocity to early diastolic mitral annular velocity (E/E') 12 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Internal Medicine,Dong-A University College of Medicine
🇰🇷Busan, Korea, Republic of