The Effects Of Anticholinergic Burden On Daily Living Activities In Elderly Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 180
- 主要终点
- The Barthel Index for Activities of Daily Living (ADL)
研究概览
简要总结
The anticholinergic burden was calculated based on the medications that the patients had used for more than 10 days. Short-term medications used by patients were not evaluated. Among all the medications used by the patients, those with anticholinergic effects were scored according to the scale, and the total anticholinergic burden was calculated by adding them up. Those who had no anticholinergic score were considered to have no anticholinergic burden.
The study cohort will be stratified into two cohorts, distinguished by the presence or absence of anticholinergic burden. To evaluate the impact of anticholinergic burden on daily living activities and instrumental ADL, the groups will be compared with respect to hand grip strength and walking speed.In this study, the anticholinergic burden will be calculated based on medications used by the patients for more than 10 days, excluding short-term medications. Each medication with anticholinergic effects will be assigned a score according to a scale, and the total anticholinergic burden will be determined by summing up the scores. Patients without any anticholinergic score will be classified as having no anticholinergic burden.
The study cohort will be divided into two groups based on the presence or absence of anticholinergic burden. To assess the impact of anticholinergic burden on daily living activities (ADLs) and instrumental ADLs, the groups will be compared in terms of hand grip strength and walking speed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being over 65 years old
- •Patients without a diagnosis of dementia and with MMSE>24
- •Patients who can communicate (without hearing or visual problems)
- •Those who give written consent to participate in the study
排除标准
- •Patients with a diagnosis of dementia at their initial visit,
- •Bedridden patients (those with visual impairments)
- •Patients with walking difficulties (due to pain, prostheses, visual problems, etc.), vitamin D deficiency (10) (20ng/dl>) or those who use assistive devices (walker, cane, etc.) or those with sequelae of cerebrovascular events or hip fractures.
- •Patients with a diagnosis of delirium,
- •Those who underwent major surgery in the last 6 months,
- •Those who experienced cardiac or cerebrovascular events during the follow-up period,
- •Patients with infectious diseases,
- •Those who did not sign or withdrew their consent form.
结局指标
主要结局
The Barthel Index for Activities of Daily Living (ADL)
时间窗: 24 hours
ADL was evaluated on a scale of 100 points according to the patients' ability to feed themselves, bathe, perform personal hygiene, dress and undress, control bowel and bladder, use the toilet independently, use a wheelchair, mobility status, and ability to climb stairs.
次要结局
- Walking speed(2 minute)
- The Lawton-Brody Instrumental Activities of Daily Living (IADL)(24 hours)
- Hand grip strength(1 minute)
研究者
hasan oztin
Head of Geriatrics
Izmir Ataturk Training and Research Hospital