The Effects of Rhus Coriaria L. on Body Weight

Not Applicable

Completed

• Conditions: Body Weight
• Interventions: Drug: Placebo; Drug: Rhus Coriaria L.(Rhus)

• Registration Number: NCT02754089
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

Detailed Description

Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

Study Timeline

• Study First Submitted: 2016-04-26
• Study First Submitted QC: 2016-04-26
• Study First Posted: 2016-04-28
• Study Start: 2016-05
• Status Verified: 2016-09
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Last Update Submitted: 2018-08-22
• Last Update Posted: 2018-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Body mass index (BMI) >= 25 kg/m2

Exclusion Criteria

• Diabetes mellitus
• Hypo. or hyperthyroidism
• Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
• Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
• Pregnancy
• History of allergic reaction to Somagh

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	500 mg twice daily after meal for 6 weeks
Rhus	Rhus Coriaria L.(Rhus)	500 mg twice daily after meal for 6 weeks

Primary Outcome Measures

Name	Time	Method
Body Mass Index	6 weeks

Secondary Outcome Measures

Name	Time	Method
Waist Circumference (cm)	6 weeks
Hip Circumference (cm)	6 weeks
Leptin (ng/ml)	6 weeks
Insulin (mU/l)	6 weeks
Fasting Blood Glucose (mg/dl)	6 weeks
Number of patients with adverse event	6 weeks

Trial Locations

Locations (1)

Shahid Motahhari Clinic, Shiraz University of Medical Sciences; 🇮🇷 Shiraz, Fars, Iran, Islamic Republic of