The adenosine receptor; a new pharmacological tool in the treatment of sepsis.

Phase 2

• Conditions: septic shock; systemic inflammation; 10083624; 10002252

• Registration Number: NL-OMON31085
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 33

Inclusion Criteria

Healthy male volunteers (no relevant medical history, no medication)
no history of syncope
age 18-35 years
non-smokers

Exclusion Criteria

History of syncope

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Effect on inflammation (temperature, C-reactive protein (crp), white blood<br /><br>count)<br /><br>- concentrations of pro- and anti-inflammatory cytokines and adenosine<br /><br>- vascular (dys)function:<br /><br>- effects on norepinephrine<br /><br>- effects on endothelial function<br /><br>- circulation endothelial cells.<br /><br>- Renal failure (specific markers for tissue damage)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>adenosine concentrations</p><br>