Prepare for kidney care

Not Applicable

• Conditions: Renal failure; Urological and Genital Diseases

• Registration Number: ISRCTN17133653
• Lead Sponsor: orth Bristol NHS Trust

Brief Summary

2021 Other publications in https://pubmed.ncbi.nlm.nih.gov/32940683/ Background and recruitment progress (added 05/05/2023)

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-31
• Last Update Posted: 9 September 2024
• Study Completion: 2025-08-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 448

Inclusion Criteria

Patients known to renal services with new or existing stage 5 CKD (eGFR <15, with at least one result confirming this in the last 12 months) and:
1. Aged 65+ with a World Health Organisation (WHO) performance status 3+ (0 = Fully active, able to carry out all normal activity without restriction; 1 = Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature; 2 = Ambulatory and capable of all self-care but unable to carry out any work activities; up and about more than 50% of waking hours; 3 = Symptomatic and in a chair or in bed for greater than 50% of the day but not bedridden; 4 = Completely disabled; cannot carry out any self-care; totally confined to bed or chair), or
2. Aged 65+ with a Davies co-morbidity score 2+ (each of the following scores one point: Malignancy, ischaemic heart disease, peripheral vascular disease (including stroke), left ventricular dysfunction, diabetes mellitus, systemic collagen vascular disease, other significant pathology (including COPD, cirrhosis, psychiatric illness, HIV), or
3. Aged 80+

Exclusion Criteria

1. Unable to consent, e.g. significant cognitive impairment or psychiatric disorder
2. Not medically fit for dialysis
3. Within 4 weeks of starting dialysis

Added 01/07/2019:
4. Patients that have had a previous kidney transplant
5. Patients that are 'active' on the kidney transplant waiting list or being worked up for the kidney transplant waiting list

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean total of quality-adjusted life years (QALY) between the first patient recruited and the end of data collection is collected using the EQ-5D-5L at recruitment and every 4 months thereafter until 31 August 2025 (end of data collection).<br><br>Updated 01/08/2024 to change the end of data collection from 1 October 2021 to 31 August 2025.