Role of Dexmedetomidine as an Adjuvant in External Oblique Intercostal Plane Block for Post Thoracotomy Pain: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Time to the 1st rescue analgesia
研究概览
简要总结
This study aims to evaluate the role of dexmedetomidine as an adjuvant in external oblique intercostal plane block for post-thoracotomy pain.
详细描述
External oblique intercostal plane block (EOIPB) is a novel block that has been described as an important modification of the fascial plane blocks that can consistently involve the upper lateral abdominal walls.
Dexmedetomidine is a selective alpha 2- adrenoceptor agonist possessing sedative, anxiolytic, and analgesic properties without the development of respiratory depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Both sexes.
- •American Society of Anesthesiology (ASA) physical status I-III.
- •Scheduled for open thoracotomy.
排除标准
- •Patients with neurological or intellectual disability.
- •Infection at the injection site.
- •Drug abuse.
- •Allergic reaction to local anesthetics.
- •Coagulation abnormalities.
- •Pregnancy.
- •Body Mass Index (BMI) ≥35 kg/m
- •Severe cardiovascular problems.
- •Diabetic neuropathy.
研究组 & 干预措施
Dexmedetomidine group
Patients will receive 29 ml bupivacaine 0.25% + 1 ml dexmedetomidine 0.5 μg/kg.
干预措施: Dexmedetomidine (Drug)
Control group
Patients will receive 29 ml bupivacaine 0.25% + 1 ml saline.
干预措施: Saline (Drug)
结局指标
主要结局
Time to the 1st rescue analgesia
时间窗: 48 hours postoperatively
Time to the first request for the rescue analgesia (time from end of surgery to first dose of morphine administrated) will be recorded.
次要结局
- Intraoperative fentanyl consumption(Intraoperatively)
- Total morphine consumption(48 hours postoperatively)
- Degree of pain(48 hours postoperatively)
- Heart rate(Every 15 min till the end of surgery)
- Mean arterial pressure(Every 15 min till the end of surgery)
- Incidence of adverse events(48 hours postoperatively)
研究者
Mohammed Said ElSharkawy
Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University