Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure
- Conditions
- Acute-On-Chronic Liver FailureAcute Kidney Injury
- Registration Number
- NCT04525625
- Lead Sponsor
- Institutul Clinic Fundeni
- Brief Summary
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
- patients admitted to the ICU for acute-on-chronic liver failure
- pre-existing renal disease
- urine output<200 mL/day
- death within the first 24 hours after ICU admission
- emergency liver transplantation within the follow-up period (28 days)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method AKI 28 days after ICU admission incidence (%) of AKI in patients with AoCLF as defined by Acute Kidney Injury Network guidelines
- Secondary Outcome Measures
Name Time Method arterial to urinary oxygen gradient ICU admission, ICU day 1 and ICU dy 3 mathematical difference in oxygen partial pressure between arterial blood and urine (mmHg) in patients with AKI compared to patients without AKI
mortality 28-days 28-day mortality
Trial Locations
- Locations (1)
Popescu Mihai
🇷🇴Bucharest, Romania