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Clinical Trials/NCT00619086
NCT00619086
Completed
Not Applicable

Does a Single Dose of Steroid Before Thyroidectomy Improve Postoperative Nausea, Pain and Vocal Function?

University of Bern1 site in 1 country72 target enrollmentNovember 2005
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ConditionsThyroid Surgery for Benign Disease
InterventionsPlaceboDexamethason Helvepharm ®
DrugsDexamethason Helvepharm ®Placebo

Overview

Phase
Not Applicable
Intervention
Placebo
Conditions
Thyroid Surgery for Benign Disease
Sponsor
University of Bern
Enrollment
72
Locations
1
Primary Endpoint
Nausea
Status
Completed
Last Updated
17 years ago
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

Registry
clinicaltrials.gov
Start Date
November 2005
End Date
June 2007
Last Updated
17 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •Patients undergoing thyroid surgery for benign disease

Exclusion Criteria

  • •Depression
  • •Chronic pain disorder
  • •Insulin dependent diabetes mellitus
  • •History of PONV
  • •Pregnancy
  • •Age \< 18 years
  • •Received antiemetic therapy within 48 hours

Arms & Interventions

A, 1

Placebo 45 minutes prior to surgery

Intervention: Placebo

A, 2

8 mg Dexamethasone 45 minutes prior to surgery

Intervention: Dexamethason Helvepharm ®

Outcomes

Primary Outcomes

Nausea

Time Frame: 0-72 hours postoperative

Secondary Outcomes

  • Pain, vocal function(0-72 hours postoperative)

Study Sites (1)

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