DRKS00031316
尚未招募
3 期
PET-guided Radiosurgery of Oligometastatic Cancer - PETOC
Städtisches Klinikum Dessau0 个研究点目标入组 198 人2023年3月2日
概览
- 阶段
- 3 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Oligometastasis wth two to five extracranial and not more than three ZNS lesions
- 发起方
- Städtisches Klinikum Dessau
- 入组人数
- 198
- 状态
- 尚未招募
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •ICD\-10: C00\-25, C30\-34(NSCLC only), C37, C39, C44\-45, C48, C50 (hormone\-resistant only), C51\-58, C60\-61 (castration\-resistant only), C63\-69, C73\-74, and C80
- •oligometastatic disease with \=5 extracranial lesions and \=3 intrecebral lesions wihtout presious treatment, after relapse after complete remission or partial remission
- •patient qualifies for cytotoxic systemic therapy
- •normal blood counts (Hb\>8g/dl, ANC\>1500/mm³, thrombocytes \>100 000/mm³)
- •normal liver function tests (ASAT/ALAT/AP\=2\.5\*ULN), if liver metastatic and to be treated: \<5\*ULN
- •Bilirubin \<1,5\*ULN
- •Creatinin clearance (Cockroft\-Gault) \> 50 ml/min
- •ability to understand research protocol and willing to comply with reassessments and follow\-ups
- •consent to have the patient’s case re\-discussed in interdisciplinary tumor boards.
- •negative pregnancy test for female patients aged \<50 yrs.
排除标准
- •Extragonadal germ cell tumor
- •Tumor or carcinoma with neuroendocrine features
- •Peritoneal carcinomatosis
- •Hormone\-sensitive breast cancer
- •Hormone\-sensitive prostate cancer
- •Chorioncarcinoma
- •Hematooncological neoplasia
- •Chemotherapy within the last three months
- •Age \= 18 yrs.
- •previous radiotherapy to at least one of the areas currently presenting with oligometastatic disease, exceptions are brain metastasis, and metastasis with compression of the spinal cord
结局指标
主要结局
未指定
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