Personalisation of a biomechanical tongue model for the prediction of treatment outcome.

Completed

• Conditions: 10019190; Tongue cancer; 10027656

• Registration Number: NL-OMON45672
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Primary tongue or tongue base cancer (T1-T3).
Primary surgery or chemoradiation treatment.
Older than 18 years
Informed consent

Exclusion Criteria

Previous history of oral or oropharyngeal cancer
Recurrent or residual tongue/tongue base cancer
Patients that are not eligible for MRI

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>A personalized prediction of functional consequences after treatment using a<br /><br>biomechanical model of the tongue and tongue base.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Range of motion endpoints<br /><br>* Range of tongue motion before and after operation.<br /><br>* Additional questionnaires regarding tongue function ( appendix)<br /><br>* Tongue muscle strength (IOPI) before intervention<br /><br>* Tongue muscle strength (IOPI) after intervention<br /><br><br /><br>Elastography endpoints<br /><br>* Elasticity of tongue tissue before intervention<br /><br>* Elasticity of scar tissue / irradiated tissue<br /><br><br /><br>MRI endpoints<br /><br>* Tongue muscular anatomy before and after partial glossectomy<br /><br>* Tongue functionality before and after partial glossectomy<br /><br><br /><br>Resection profile endpoints<br /><br>* Dimensions of the resection intraoperatively.<br /><br>* Dimensions of the specimen.</p><br>