Continuous neuromonitoring in critically ill patients

Completed

Conditions: epileptic seizures
10039911
convulsions

Registration Number: NL-OMON34917

Lead Sponsor: Klinische neurofysiologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

Age 18 years or older
glasgow coma scale < 9 and admitted to the ICU
One of the following conditions: intracerebral hemorrhage; subarachnoid hemorrhage; ischemic stroke; severe traumatic brain injury; (meningo)encephalitis; post-anoxic encephalopathy; intracranial surgery; (non)convulsive status epilepticus; cardiac arrest or ventricular fibrillation with cardial resuscitation

Exclusion Criteria

Severe skull injuries making EEG-electrode application impossible

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint will be the sensitivity and specificity of the<br /><br>developed monitoring system for detection of secondary events (seizures, focal<br /><br>cerebral ischemia) as compared to the gold standard (evaluation of the EEG by a<br /><br>clinical neurophysiologist).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>An important secundairy endpoint will be the feasibility of cEEG.<br /><br><br /><br>Other secondary studypparameters are mainly observational and are useful for<br /><br>future implementation of the developed monitoring system:<br /><br>1. The prevalence of nonconvulsive seizures in critically ill patients.<br /><br>2. What patients groups are most at risk for developing seizures?<br /><br>3. Does the information gained by cEEG measurement have impact on clinical<br /><br>patient management, for instance on therapeutic decision making?<br /><br>4. Is it possible to detect the development of cerebral ischemia by continuous<br /><br>EEG monitoring before clinical symptoms occur?<br /><br>5. Is brain function, as measured by cEEG monitoring, influenced by general<br /><br>health events such as hypotension, bradycardia and decrease of oxygen<br /><br>saturation? </p><br>