Immunmodulation in Patients With HHT
- Conditions
- Hereditary Haemorrhagic Telangiectasia (HHT)
- Interventions
- Other: blood sample
- Registration Number
- NCT02983253
- Lead Sponsor
- University Hospital, Essen
- Brief Summary
Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder. Literature suggests that HHT is often associated with higher frequency of infectious diseases.
The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.
- Detailed Description
Hereditary haemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is an inherited multisystemic disorder with recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations. Literature and the investigators' observation suggest that HHT is often associated with higher frequency of infectious diseases. This might be a hint for a immunocompromised situation.
The purpose of this study is to evaluate a variety of immunologic parameters in the blood serum of HHT patients in comparison to probands.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 124
- aged 18 or over, HHT
- Unable to provide informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with HHT blood sample blood sample of patients with HHT probands blood sample blood sample of healthy controls
- Primary Outcome Measures
Name Time Method Amounts of leucocytes in patients with HHT November 2016 - December 2018
- Secondary Outcome Measures
Name Time Method Differences in distribution of leucocytes in patients with HHT November 2016 - December 2018
Trial Locations
- Locations (1)
University Hospital Essen
🇩🇪Essen, Germany