Development of a broader understanding of Vitamin D levels in patients undergoing sleeve gastrectomy to inform guidelines for post-surgery supplementatio

Not Applicable

Completed

• Conditions: Vitamin D deficiency; Morbid Obesity; Diet and Nutrition - Obesity; Diet and Nutrition - Other diet and nutrition disorders

• Registration Number: ACTRN12615000579594
• Lead Sponsor: The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

(i)Age 18-65 years
(ii) Available to participate in data collection prior to surgery, six and 12 months post surgery
(iii) Meet criteria within the International Sleeve Gastrectomy Expert Panel Consensus Statement for surgery

Exclusion Criteria

(i)Pregnant
(ii)<18yrs
(iii)Inability to provide informed consent due to diminished understanding or comprehension, or a language other than English spoken and an interpreter unavailable
(iv)Taking medications that interfere with vitamin D metabolism

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum 25(OH)D<br>[baseline, 6 and 12 months post surgery]

Secondary Outcome Measures

Name	Time	Method
Serum PTH[baseline, 6 and 12 months post surgery];Serum ionised Calcium[baseline, 6 and 12 months post surgery];BMI[baseline, 6 and 12 months post surgery];Dietary assessment using the Woollongong Diet history[baseline, 6 and 12 months post surgery];Sun exposure assessment via questionnaire designed specifically for this study based on a previously used questionnaire in the Suncorp Sun study. [baseline, 6 and 12 months post surgery];Expression of CYP24A1 via qPCR[Baseline ];Expression of CYP27A1 via qPCR[Baseline];Expression of CYP27B1 via qPCR[Baseline];Expression of VDR via qPCR[Baseline];SNP analysis of VDR gene [baseline];SNP analysis of vitamin D binding protein[baseline]