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临床试验/NCT03519828
NCT03519828已完成不适用

Effects of Oxidation-reduction Homeostasis on Cognitive Impairment in Patients With Ischemic Stroke

Hui-Sheng Chen1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2018年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
100
试验地点
1
主要终点
Oxidative-reduction homeostasis in acute ischemic stroke patients

研究概览

简要总结

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
40 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 40-80 years old;
  • Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
  • Time from onset to treatment ≤48 hours;
  • Conscious awareness, and with no obvious aphasia and visual impairment;
  • Signed informed consent by patient self or legally authorized representatives.

排除标准

  • Intracranial hemorrhage or suspected subarachnoid hemorrhage;
  • Transient ischemic attack;
  • Patients with severe mental disorders or language disorders;
  • Patients can not cooperate with evaluators, such as mental illness or dementia;
  • Pregnant women or suckers;
  • Researchers consider patients inappropriate to participate in the registry.

结局指标

主要结局

Oxidative-reduction homeostasis in acute ischemic stroke patients

时间窗: 1 day

Reduced glutathione (GSH)/ Oxidized glutathione (GSSG), Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-PX) of acute ischemic stroke patients will be tested.

Cognitive function in acute ischemic stroke patients

时间窗: 1 day

Mini Mental Status Examination (MMSE) and Montreal cognitive assessment scale (MoCA) in acute ischemic stroke patients will be evaluated.

次要结局

未报告次要终点

研究者

发起方
Hui-Sheng Chen
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Hui-Sheng Chen

Professor

General Hospital of Shenyang Military Region

研究点 (1)

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