Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

Completed

• Conditions: Post-stroke Cognitive Impairment; Oxidative-reduction Homeostasis
• Interventions: Other: No intervention has been conducted

• Registration Number: NCT03519828
• Lead Sponsor: Hui-Sheng Chen

Brief Summary

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-01
• Study First Submitted: 2018-04-15
• Study First Submitted QC: 2018-04-26
• Study First Posted: 2018-05-09
• Primary Completion: 2018-12-30
• Study Completion: 2019-01-01
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-29
• Last Update Posted: 2019-07-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 40-80 years old;
• Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
• Time from onset to treatment ≤48 hours;
• Conscious awareness, and with no obvious aphasia and visual impairment;
• Signed informed consent by patient self or legally authorized representatives.

Exclusion Criteria

• Intracranial hemorrhage or suspected subarachnoid hemorrhage;
• Transient ischemic attack;
• Patients with severe mental disorders or language disorders;
• Patients can not cooperate with evaluators, such as mental illness or dementia;
• Pregnant women or suckers;
• Researchers consider patients inappropriate to participate in the registry.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients without post-stroke cognitive impairment	No intervention has been conducted	-
Patients with post-stroke cognitive impairment	No intervention has been conducted	-

Primary Outcome Measures

Name	Time	Method
Oxidative-reduction homeostasis in acute ischemic stroke patients	1 day	Reduced glutathione (GSH)/ Oxidized glutathione (GSSG), Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-PX) of acute ischemic stroke patients will be tested.
Cognitive function in acute ischemic stroke patients	1 day	Mini Mental Status Examination (MMSE) and Montreal cognitive assessment scale (MoCA) in acute ischemic stroke patients will be evaluated.

Trial Locations

Locations (1)

General Hospital of ShenYang Military Region; 🇨🇳 Shenyang, Liaoning, China