临床试验/NCT00630721

NCT00630721已完成不适用

Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

University of North Carolina, Chapel Hill1 个研究点分布在 1 个国家目标入组 56 人开始时间: 2007年9月1日最近更新: 2018年10月18日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: University of North Carolina, Chapel Hill
入组人数: 56
试验地点: 1
主要终点: Determine the effect of IFN-B-1b-induced SOCS3 upregulation in DCs' on their maturation and the capacity to present

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Determine the in-vivo mechanism of action of INF-B-1b as it's mechanisms of action are not completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces tolerizing effect on DC-dependent T-cell differentiation in patients with MS by inducing the expression of SOCS3 in DCs.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Basic Science
盲法: None

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Confirmed diagnosis of MS
•Age 18-60 years, inclusive
•Expanded disability status of 0-6.5
•Give written informed consent prior to any testing under this protocol

排除标准

未提供

研究组 & 干预措施

IFNbeta-1b

Other

no drug was given under study. patients already taking IFNbeta-1b were enrolled for blood draw only.

干预措施: IFNbeta-1b (Other)

结局指标

主要结局

Determine the effect of IFN-B-1b-induced SOCS3 upregulation in DCs' on their maturation and the capacity to present

时间窗: 2 years

次要结局

Characterize the effect of IFN-1b-induced SOCS3 expression in DCs on Th1/Th2 cell differentiation and T-cell cytokine transcription.(2 years)

研究者

发起方

University of North Carolina, Chapel Hill

申办方类型

Other

责任方

Sponsor

研究点 (1)

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