Early pharmacological intervention to prevent delirium: HAlopeRidol PrOphylaxis in Older emergency department patieNts.The HARPOON study - Haloperidol prophylaxis in older acutely admitted patients

VU Univeristy Medical Centre0 sitesMay 7, 2012

Overview

No summary available.

Registry

who.int

Start Date

May 7, 2012

End Date

TBD

Last Updated

10 years ago

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

VU Univeristy Medical Centre

•\- Patients aged 70 years or over;
•\- The patient is at increased risk for developing in\-hospital delirium on admission according to one or more positive answers on the VMS delirium\-risk questions;
•\- The patient or proxy is able to provide written informed consent;
•\- The patient or proxy speaks either Dutch or English;
•\- The patient is admitted to the hospital for an internal or surgical specialty.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) no
•F.1\.2\.1 Number of subjects for this age range
•F.1\.3 Elderly (\>\=65 years) yes

•\- Patients presenting in the ED with delirium according to the DSM\-IV criteria;
•\- Patients with clinically significant (cardiac) disorders: QTc interval prolongation (QTc \= 500ms), recent acute myocardial infarction, uncompensated heart failure (working diagnosis), acute coronary syndrome (ACS), arrhythmias treated with class IA and III antiarrhythmic medicinal products, history of ventricular arrhythmia, history of torsade de pointes, clinically significant bradycardia, second or third degree heart block, uncorrected hypokalaemia (potassium level 3\.0 or lower);
•\- Patients with vascular dementia;
•\- Patients with Lewy Body dementia;
•\- Patients with Parkinson (dementia);
•\- Patients with (a history of) hypokinetic movement disorders;
•\- Patients with (a history of) malignant neuroleptic syndrome;
•\- Patients with (a history of) serotonergic syndrome;
•\- Patients with (a history of) central anticholinergic syndrome;
•\- Patients who will be admitted to the oncology ward;