Effect of Carvedilole compared to Terazosin plus Enalapril in treatment of Hypertension and benign prostatic hyperplasia

Phase 3

Conditions: Condition 1: Hypertension. Condition 2: Benign prostate hyperplasia.
Essential (primary) hypertension
Enlarged prostate with lower urinary tract symptoms

Registration Number: IRCT20181128041777N1

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Male

Target Recruitment: 40

Inclusion Criteria

Moderate hypertension (according European guide line blood pressure between 140-159 in systolic and 90-99 in diastolic)
Men above 40 years with benign prostatic hyperplasia that diagnosis with permanent LUTS during the last 6 months ,physical examination, ultrasonography and serum PSA

Exclusion Criteria

History of using alfa blockers during the last 6 months
history of uncontrolled or malignant urgency HTN
history of using anti hypertensive and prostate drugs
history of prostate cancer
history of prostate surgery

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Q max: Maximum urinary flow rate show in uroflowmetry. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: uroflowmetry.

Secondary Outcome Measures

Name	Time	Method
PVR :Post Voiding Residual. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: Sonography.;IPSS : international prostate symptom score. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: International prostate symptom score questionnaire.;PSA : prostate specific antigen. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: Blood test.;Systolic blood pressure. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: mercury manometer.;Diastolic blood pressure. Timepoint: in 4 time: before treatment. after carvedilol. before enalapril and terazosin and after that. Method of measurement: mercury manometer.