Effect of metformin on the volume of cysts and kidneys in poly-cystic kidney disease patients

Phase 2

• Conditions: Polycystic kidney disease.; Polycystic Kidney, autosomal dominant; Polycystic kidney adult type

• Registration Number: IRCT2013021912527N1
• Lead Sponsor: Vice chancellor for research, Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Serum creatinine less than 1.4mg/dL at the beginning of the study; signing the informed consent form
Exclusion criteria:
previous history of metformin use; allergy to metformin; any side effect during the intervention which prevents the patient from continuing the study

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Volume of cyst. Timepoint: Before and after intervention. Method of measurement: MRI.;Kidney volume. Timepoint: Before and after intervention. Method of measurement: MRI.

Secondary Outcome Measures

Name	Time	Method
Serum creatinine. Timepoint: Before and after intervention. Method of measurement: Jaffe method.;24h-Urine protein. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Serum IL-6. Timepoint: Before and after intervention. Method of measurement: kit.;Serum CRP. Timepoint: Before and after intervention. Method of measurement: Kit.;GFR. Timepoint: Before and after intervention. Method of measurement: Calculation.