NL-OMON48828
Completed
Not Applicable
Predicting Treatment Resistance in Schizophrenia - TREVOS
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- first episode psychosis
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 120
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For patients:
- •\- First episode psychosis
- •\- Age 18\-35 years old;For healthy contols:
- •\- Age 18\-35 years old
Exclusion Criteria
- •\- Antipsychotic use longer than one year
- •\- Dependence on other substances of abuse than nicotine or cannabis
- •\- Use of amphetamine, cocaine or medication for ADHD (attention deficit hyperactivity disorder), since these drugs influence the dopamine system
- •\- Neurological disorder (e.g. epilepsy) or evidence of brain damage
- •\- Inability to provide informed consent;In addition to the exclusion criteria mentioned above, healthy control subjects are not allowed to have any kind of psychiatric disorder;Exclusion criteria directly related to MRI scanning:
- •\- Contra\-indications for MRI (including pacemaker, ferromagnetic implants, claustrophobia)
- •\- Pregnancy;Exclusion criteria directly related to PET/CT scanning (for subgroup of 40 patients):
- •\- Participation in a scientific examination where radiation was used, in the last year.
- •\- Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates. Only recent cannabis use will be accepted.
- •\- In women: positive pregnancy test on the day of the PET/CT scan and lactation.
Outcomes
Primary Outcomes
Not specified
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