Skip to main content
Clinical Trials/NCT05260307
NCT05260307RecruitingNot Applicable

Improving Spatial Perception and Speech Understanding in Multitalker Mixtures

Boston University Charles River Campus1 site in 1 country220 target enrollmentStarted: March 9, 2022Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Recruiting
Sponsor
Enrollment
220
Locations
1
Primary Endpoint
Speech intelligibility at baseline

Study Overview

Brief Summary

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.

Detailed Description

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. Aim 1 will investigate how well different amplification strategies provide access to the spectrotemporally sparse speech information that is available in multitalker mixtures. The hypothesis is that subtle differences in high-frequency audibility across different strategies may have much greater effects on the intelligibility of sparse speech than intact speech. This Aim will involve 40 subjects with hearing loss across 2 experiments. Aim 2 is an exploratory aim that will investigate the potential of a speech enhancement algorithm to improve spatial hearing in multitalker mixtures. The hypothesis is that speech enhancement, in addition to its established monaural benefits, will enhance the salience of interaural time differences and thus provide binaural benefits in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments. Aim 3 will investigate how different hearing-aid styles affect sound externalization. The hypothesis is that hearing aids can disrupt sound externalization, which in turn impacts speech intelligibility in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments.

This is a prospective design involving adult human subjects. While the investigators will recruit subjects with normal and impaired hearing, all subjects will be assigned to the same set of experimental conditions. Therefore, for the purposes of intervention (or prospective assignment), the subjects can be treated as a single group completing the same intervention (or set of interventions). The behavioral experiments involve listening to speech sounds (either unaided, with hearing aids, or with simulated hearing aids), and providing responses related to spatial perception or speech intelligibility. The order of experimental conditions will be randomized for each subject in order to control for order effects. All of the experimental tasks and outcome measures have been previously established, have good reliability and validity, and will be appropriate for informing future studies.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Basic Science
Masking
None

Masking Description

While participants will not be informed about the specific experimental condition being tested, certain acoustical changes may be perceptible to them and thus strict masking is impossible.

Eligibility Criteria

Ages
18 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Normal-Hearing Subjects
  • •18 to 35 years of age
  • •Audiometric thresholds that do not exceed 20 dB HL at any frequency from 250 to 8000 Hz
  • •Able to provide informed consent and understand experimental instructions
  • •Normal or corrected-to-normal vision
  • •Inclusion Criteria: Hearing-Impaired Subjects
  • •18 to 80 years of age
  • •Documented sensorineural hearing loss
  • •Able to provide informed consent and understand experimental instructions
  • •Normal or corrected-to-normal vision

Exclusion Criteria

  • •(some experiments)
  • •Non-native speakers of English

Arms & Interventions

Experimental condition

Other

Participants will be presented with sound stimuli under a number of experimental conditions that simulate different hearing-aid conditions.

Intervention: hearing aid condition (Other)

Outcomes

Primary Outcomes

Speech intelligibility at baseline

Time Frame: Baseline

Speech intelligibility scores will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in percent correct (0-100%).

Speech reception threshold at baseline

Time Frame: Baseline

Speech reception thresholds will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in decibels (the level of the target speech relative to the masker speech needed to identify 50% of the words in a sentence).

Interaural time difference discrimination at baseline

Time Frame: Baseline

Thresholds for the discrimination of interaural time differences in speech will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in microseconds.

Interaural time difference discrimination post-intervention

Time Frame: Up to 4 hours

Thresholds for the discrimination of interaural time differences in speech will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in microseconds.

Speech intelligibility post-intervention

Time Frame: Up to 4 hours

Speech intelligibility scores will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in percent correct (0-100%).

Externalization rating post-intervention

Time Frame: Up to 4 hours

Externalization judgments for speech will be measured in a baseline condition (e.g. unaided) and in a number of different hearing-aid conditions (post-intervention). Scale is in percent (0-100%).

Speech reception threshold post-intervention

Time Frame: Up to 4 hours

Speech reception thresholds will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in decibels (the level of the target speech relative to the masker speech needed to identify 50% of the words in a sentence).

Externalization rating at baseline

Time Frame: Baseline

Externalization judgments for speech will be measured in a baseline condition (e.g. unaided) and in a number of different hearing-aid conditions (post-intervention). Scale is in percent (0-100%).

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Boston University Charles River Campus
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

Loading locations...

Similar Trials