跳至主要内容
临床试验/NCT05260307
NCT05260307招募中不适用

Improving Spatial Perception and Speech Understanding in Multitalker Mixtures

Boston University Charles River Campus1 个研究点 分布在 1 个国家目标入组 220 人开始时间: 2022年3月9日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
220
试验地点
1
主要终点
Speech intelligibility at baseline

研究概览

简要总结

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. The hypotheses are that spatial perception and speech intelligibility will be improved by (1) increased high-frequency audibility, (2) speech envelope enhancement, and/or (3) appropriate sound image externalization.

详细描述

The purpose of this study is to investigate several approaches for improving spatial perception and speech intelligibility in multitalker listening situations for hearing-aid users. Aim 1 will investigate how well different amplification strategies provide access to the spectrotemporally sparse speech information that is available in multitalker mixtures. The hypothesis is that subtle differences in high-frequency audibility across different strategies may have much greater effects on the intelligibility of sparse speech than intact speech. This Aim will involve 40 subjects with hearing loss across 2 experiments. Aim 2 is an exploratory aim that will investigate the potential of a speech enhancement algorithm to improve spatial hearing in multitalker mixtures. The hypothesis is that speech enhancement, in addition to its established monaural benefits, will enhance the salience of interaural time differences and thus provide binaural benefits in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments. Aim 3 will investigate how different hearing-aid styles affect sound externalization. The hypothesis is that hearing aids can disrupt sound externalization, which in turn impacts speech intelligibility in multitalker mixtures. This Aim will involve 30 subjects with normal hearing and 60 subjects with hearing loss across 3 experiments.

This is a prospective design involving adult human subjects. While the investigators will recruit subjects with normal and impaired hearing, all subjects will be assigned to the same set of experimental conditions. Therefore, for the purposes of intervention (or prospective assignment), the subjects can be treated as a single group completing the same intervention (or set of interventions). The behavioral experiments involve listening to speech sounds (either unaided, with hearing aids, or with simulated hearing aids), and providing responses related to spatial perception or speech intelligibility. The order of experimental conditions will be randomized for each subject in order to control for order effects. All of the experimental tasks and outcome measures have been previously established, have good reliability and validity, and will be appropriate for informing future studies.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

盲法说明

While participants will not be informed about the specific experimental condition being tested, certain acoustical changes may be perceptible to them and thus strict masking is impossible.

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Normal-Hearing Subjects
  • •18 to 35 years of age
  • •Audiometric thresholds that do not exceed 20 dB HL at any frequency from 250 to 8000 Hz
  • •Able to provide informed consent and understand experimental instructions
  • •Normal or corrected-to-normal vision
  • •Inclusion Criteria: Hearing-Impaired Subjects
  • •18 to 80 years of age
  • •Documented sensorineural hearing loss
  • •Able to provide informed consent and understand experimental instructions
  • •Normal or corrected-to-normal vision

排除标准

  • •(some experiments)
  • •Non-native speakers of English

研究组 & 干预措施

Experimental condition

Other

Participants will be presented with sound stimuli under a number of experimental conditions that simulate different hearing-aid conditions.

干预措施: hearing aid condition (Other)

结局指标

主要结局

Speech intelligibility at baseline

时间窗: Baseline

Speech intelligibility scores will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in percent correct (0-100%).

Speech reception threshold at baseline

时间窗: Baseline

Speech reception thresholds will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in decibels (the level of the target speech relative to the masker speech needed to identify 50% of the words in a sentence).

Interaural time difference discrimination at baseline

时间窗: Baseline

Thresholds for the discrimination of interaural time differences in speech will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in microseconds.

Interaural time difference discrimination post-intervention

时间窗: Up to 4 hours

Thresholds for the discrimination of interaural time differences in speech will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in microseconds.

Speech intelligibility post-intervention

时间窗: Up to 4 hours

Speech intelligibility scores will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in percent correct (0-100%).

Externalization rating post-intervention

时间窗: Up to 4 hours

Externalization judgments for speech will be measured in a baseline condition (e.g. unaided) and in a number of different hearing-aid conditions (post-intervention). Scale is in percent (0-100%).

Speech reception threshold post-intervention

时间窗: Up to 4 hours

Speech reception thresholds will be measured in a baseline condition (e.g. unaided) and in a number of hearing-aid conditions (post-intervention). Scale is in decibels (the level of the target speech relative to the masker speech needed to identify 50% of the words in a sentence).

Externalization rating at baseline

时间窗: Baseline

Externalization judgments for speech will be measured in a baseline condition (e.g. unaided) and in a number of different hearing-aid conditions (post-intervention). Scale is in percent (0-100%).

次要结局

未报告次要终点

研究者

发起方
Boston University Charles River Campus
申办方类型
Other
责任方
Sponsor

研究点 (1)

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