se of advanced magnetic resonance imaging (MRI) technology to improve understanding and diagnosis of the major neurodegenerative diseases.

niversity of Queensland0 sites400 target enrollmentDecember 19, 2018

Overview

No summary available.

Registry

who.int

Start Date

December 19, 2018

End Date

TBD

Last Updated

6 years ago

Study Type

Observational

Sex

All

Sponsor

niversity of Queensland

•oVisual and auditory acuity, adequate for neuropsychological testing
•oEnglish language proficiency, adequate for comprehensive neuropsychological testing
•oWilling to undergo repeated MRIs (3T and 7T MRIs)
•oHealthy control: without any history of neurological or major psychiatric illness; and who are free of any cognitive symptoms (e.g. Mini Mental State Exam (MMSE) score greater than or equal to 26/30, Addenbrooke’s Cognitive Examination (ACE) score greater than or equal to 88/100, Clinical Dementia Rating (CDR) equal to 0 ) ; and whose general health is good enough to lie comfortably in an MRI scanner (e.g. does not have severe arthritis or breathlessness etc.)
•oPatients group will be divided into 7 different subgroups based on their clinical diagnosis.\*
•oPatient Group 1: Alzheimer’s disease (AD), including prodromal states such as mild cognitive impairment
•oPatient Group 2: Parkinson’s disease (PD) patients
•oPatient Group 3: Dementia with Lewy Bodies (DLB)
•oPatient Group 4: Frontotemporal dementia (FTD)
•oPatient Group 5: Progressive supranuclear palsy (PSP)

•oPregnancy\#
•oKnown history of claustrophobia\#
•oContra\-indication to MRI\#: cardiac pacemakers, aneurysm clips, metal implants, hearing aid/implant, electrical neurostimulators, joint replacement etc. in accordance with the standard operating procedures of the Centre for Advanced Imaging, UQ. \#NOTE: Participants will be re\-interviewed by a radiographer on the day of imaging at the Centre for Advanced Imaging, UQ.
•oHistory of other neurological diseases (including clinical stroke, multiple sclerosis, tumour, epilepsy, or any other disease) that could confound interpretation of the MRI scan data
•oHistory of major psychiatric illness (psychosis, major depression)
•oAny medical condition that could make scanning hazardous/uncomfortable (e.g. difficulty lying flat due to cardiac, respiratory or rheumatological disease)
•oFor the patient group only
•oUnavailability of a close relative/companion who can assist the patient to attend the research facility.
•oAdvanced cognitive impairment rendering the patient untestable on neuropsychological tests or unable to follow the instructions for MRI scanning.