ACTRN12618002032235招募中未知
se of advanced magnetic resonance imaging (MRI) technology to improve understanding and diagnosis of the major neurodegenerative diseases.
niversity of Queensland0 个研究点目标入组 400 人开始时间: 2018年12月19日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40 Years 至 80 Years（—）
- 性别
- All
入选标准
- •oVisual and auditory acuity, adequate for neuropsychological testing
- •oEnglish language proficiency, adequate for comprehensive neuropsychological testing
- •oWilling to undergo repeated MRIs (3T and 7T MRIs)
- •oHealthy control: without any history of neurological or major psychiatric illness; and who are free of any cognitive symptoms (e.g. Mini Mental State Exam (MMSE) score greater than or equal to 26/30, Addenbrooke’s Cognitive Examination (ACE) score greater than or equal to 88/100, Clinical Dementia Rating (CDR) equal to 0 ) ; and whose general health is good enough to lie comfortably in an MRI scanner (e.g. does not have severe arthritis or breathlessness etc.)
- •oPatients group will be divided into 7 different subgroups based on their clinical diagnosis.*
- •oPatient Group 1: Alzheimer’s disease (AD), including prodromal states such as mild cognitive impairment
- •oPatient Group 2: Parkinson’s disease (PD) patients
- •oPatient Group 3: Dementia with Lewy Bodies (DLB)
- •oPatient Group 4: Frontotemporal dementia (FTD)
- •oPatient Group 5: Progressive supranuclear palsy (PSP)
- •oPatient Group 6: Corticobasal degeneration (CBD), including patients with undifferentiated akinetic/rigid syndromes, i.e. where the assessing neurologist is confident of a degenerative disease but where the clinical features preclude a more precise diagnosis such as PD, PSP, CBD
- •oPatient Group 7: Amyotrophic lateral sclerosis (ALS)
- •o* Diagnosis will be based on patient and carer interview & questionnaire, physical examination, brain scans, cognitive tests (MMSE, ACE, CDR) and/or motor function tests (ALS functional rating scale revised (ALSFRS-R), Unified Parkinson’s disease rating scale (UPDRS), Hoen and Yahr).
排除标准
- •oPregnancy#
- •oKnown history of claustrophobia#
- •oContra-indication to MRI#: cardiac pacemakers, aneurysm clips, metal implants, hearing aid/implant, electrical neurostimulators, joint replacement etc. in accordance with the standard operating procedures of the Centre for Advanced Imaging, UQ. #NOTE: Participants will be re-interviewed by a radiographer on the day of imaging at the Centre for Advanced Imaging, UQ.
- •oHistory of other neurological diseases (including clinical stroke, multiple sclerosis, tumour, epilepsy, or any other disease) that could confound interpretation of the MRI scan data
- •oHistory of major psychiatric illness (psychosis, major depression)
- •oAny medical condition that could make scanning hazardous/uncomfortable (e.g. difficulty lying flat due to cardiac, respiratory or rheumatological disease)
- •oFor the patient group only
- •oUnavailability of a close relative/companion who can assist the patient to attend the research facility.
- •oAdvanced cognitive impairment rendering the patient untestable on neuropsychological tests or unable to follow the instructions for MRI scanning.
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