JPRN-UMIN000004863
Completed
Phase 3
A double-blind randomized controlled trial comparing 0.75mg of Palonosetron with 1mg of Granisetron for the control of highly emetogenic chemotherapy-induced emesis. - Trial of granisetron versus palonosetron for emesis induced by HEC(TRIPLE)
Pharma Valley Center,Shizuoka Organization for Creation Industries0 sites840 target enrollmentJanuary 12, 2011
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Malignant tumor (lung cancer,gastric cancer,esophagus cancer,cervical cancer,endometrial cancer,head and neck cancer,etc)
- Sponsor
- Pharma Valley Center,Shizuoka Organization for Creation Industries
- Enrollment
- 840
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •(1\)known prior severe hypersensitivity to 5HT3 receptor antagonist, corticosteroids and aprepitant (2\)patients who do not have enough whole body state to the antineoplastic agents treatment (3\)known symptomatic brain metastasis (4\)patients who has a convulsive disorders that need anticonvulsants therapy (5\)patients with a symptom who has ascites or pleural effusion that need puncture (6\)patients with obstruction of gastrointestinal tract,for example gastric outlet or ileus etc (7\)pregnant, breastfeeding or expecting woman (8\)patients enforced radiotherapy at the bottom of diaphragm on the period between 6 days before and 6 days after of the date of first therapy (9\)patients who take a medicine regularly ,for example , 5HT3 receptor antagonists, corticosteroids, antidopamine agonists, phenothiazine tranquilizers,antihistamine drugs, benzodiazepine,agents, etc (10\)judged by the investigator to be inappropriate for this study
Outcomes
Primary Outcomes
Not specified
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