Effects of Physical Exercise Timing On Strength and Cardiometabolic Health
- Conditions
- Physical Inactivity
- Interventions
- Other: Physical Exercise Intervention
- Registration Number
- NCT06063135
- Lead Sponsor
- University of Basel
- Brief Summary
Physical exercise is well known to improve human health. Current guidelines provide recommendations on the frequency, intensity, type and duration of exercise. However, they do not provide recommendations for the time of day, exercise should be performed. This is surprising considering that the influence of timing of behaviors such as sleep or nutrition as well as the impact of the circadian timing system on health are well documented. Further, there is evidence for diurnal variation in maximum performance which enables individuals to exercise with different intensities at different times of day, which in the long term might affect physical adaptations to exercise. Thus, this research study investigates if exercise timing impacts human health.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 152
- BMI 18.5 - 30 kg/m2
- Structured resistance training within the last six months
- Ongoing shift work
- Irregular bedtime (> 2 hours variation in habitual bed time)
- Smoking
- Travels across more than two time zones within the last four weeks
- Inability to follow the study procedures (e.g. due to language barriers, psychological disorders, dementia, etc.)
- Known pregnancy or lactating women
- Participation in any other clinical trial within the last four weeks
- Medical condition that is a contra indicator for resistance training, endurance training, or exercising until maximum exhaustion including insufficiently controlled blood pressure (systolic > 170 mmHg, diastolic > 100 mmHg), ongoing cancer treatment, unstable angina pectoris, uncontrolled bradyarrhythmia or tachyarrhythmia, severe uncorrected valvular heart disease, clinically relevant acute infection, any form of musculoskeletal injury, orthopedic problems or decompensated cardiovascular disease
- Insulin dependent diabetes
- Participants using metformin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Exercise Time 1 Physical Exercise Intervention Physical exercise intervention taking place at one time of the day Exercise Time 2 Physical Exercise Intervention Physical exercise intervention taking place at another time of day
- Primary Outcome Measures
Name Time Method Maximum strength Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention) Mean value of the maximum isometric strength assessed at four different times of the day with an isometric mid-thigh pull on a force plate.
- Secondary Outcome Measures
Name Time Method Cardiorespiratory fitness Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention) VO2max assessed with cardiopulmonary exercise test
Glucose control Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention) 2-h postprandial area under the curve for glucose after an oral glucose tolerance test
Body composition Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention) total body fat mass assessed with DXA
Trial Locations
- Locations (1)
University of Basel
🇨ðŸ‡Basel, Switzerland