Evaluation the effects of N-acetyl Cysteine on diabetic foot ulcer
- Conditions
- Diabetic Foot Ulcer.Diabetes mellitus due to underlying condition with foot ulcerE08.621
- Registration Number
- IRCT20130917014693N17
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Patients hospitalized in the infectious, internal and orthopedic departments of Loghman Hospital who have type 2 diabetes and unhealed diabetic foot ulcers
Patients with grade 3 according to the PEDIS criteria
Patients with osteomyelitis involvement proven by MRI or clinical criteria
Patients with ankle-brachial pressure index (ABI) between 0.9 and 1.3
Patients who have signed the consent form
Patients with a history of taking N-acetylcysteine, vitamin D and vitamin C in the last 2 weeks
Patients with a history of allergy to N-acetylcysteine ??or its derivatives
Patients with a history of asthma and bronchospasm
Pregnant and lactating patients
Patients taking immunosuppressive drugs
Patients who are discharged from the hospital within 1 week
Patients who have serum creatinine concentration above 2mg/d
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Area and depth of wound involvement. Timepoint: Duraing the study. Method of measurement: Sterile ruler.
- Secondary Outcome Measures
Name Time Method Inflammation factors including ESR (Erythrocyte sedimentation rate) and CRP (C-reactive protein). Timepoint: Every other day the beginning of the drug administration to the end of the study. Method of measurement: Laboratory.;White Blood Cell. Timepoint: Every other day the beginning of the drug administration to the end of the study. Method of measurement: Laboratory.;Edema. Timepoint: Once daily from the beginning of the drug administration to the end of the study. Method of measurement: Meter.