Effects of hypothermia on the disposition of morphine, fentanyl, midazolam and propofol in intensive care unit patients

The Norwegian University of Science and Technology0 个研究点目标入组 30 人开始时间: 2006年7月12日最近更新: 2021年5月10日

适应症

试验速览

暂无简介。

•Patients treated with therapeutic hypothermia (33-34°C) and a control group of critically ill patients at a normal temperature (36-38°C).
•Controls will be matched on sex, age and duration of morphine infusion.
•Patients must be 18 years or older.
•Receiving continuous analgesia/sedation with morphine and midazolam for at least 12 hours.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Pregnant women
•Cardiovascular unstable patients in deteriorating circulating status.
•Renal failure calculated or measured renal clearance to less than 30.
•Clinical significant liver failure.
•Hemoglobin < 11 g/
•Known history of drug abuse (including cocaine, opiates, amphetamines, etc.) and alcoholism
•History of drug allergies for the study drugs

发起方

The Norwegian University of Science and Technology