Is TSH Level in Serum Affect ICSI Outcome?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- ICSI outcome and its relation with TSH level
研究概览
简要总结
TSH has been suggested to be involved in reproductive challenges such as ovulatory issues, infertility, miscarriage, and maternal complications for many years.
Multiple studies have associated thyroid function with ovarian function and reproductive physiology. The thyroid hormone can impact follicle development, as well as the metabolism of estrogen and androgen, the menstrual cycle, and the receptivity of the endometrium
详细描述
In a region with adequate iodine levels, a TSH threshold of 4.12 mIU/L should be regarded as the upper limit of normal. The Chinese Society for Reproductive Medicine suggests that infertile women and those trying to conceive should consider a TSH level between 4-4.5 mIU/L for subclinical hypothyroidism.
Hence, it is recommended that women aiming for in vitro fertilization (IVF) should have a TSH level of 4 mIU/L or lower. Studies have shown that infertile patients with untreated TSH levels >2.5 mIU/L before IVF/intracytoplasmic sperm injection (ICSI) had better pregnancy results when their TSH levels were <2.5 mIU/L compared to those with TSH >2.5 mIU/L.
In this study the aim was to Examine the clinical characteristics and results in infertile individuals with varying thyroid stimulating hormone (TSH) levels during ICSI, and determining which TSH levels cutoff impact the outcomes of ICSI or not.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI): women with BMI 18 : 30 kg/m
- •Favorable (average) responders to IVF stimulation: Anti-mullirian hormone (AMH) level >1.0 ng/mL but <3.5 ng/mL and antral follicular count (AFC) 5-
- •The embryos were transferred freshly or frozen .
- •Medically free
排除标准
- •Women with polycystic ovary syndrome (PCOS).
- •Poor ovarian response.
- •Severe teratoathenospermia.
- •women with chronic disease
研究组 & 干预措施
Group A
Patients with TSH<2.5 miu/L
干预措施: Basal TSH level (Other)
Group B
Patients with TSH 2.5-4 miu/L
干预措施: Basal TSH level (Other)
结局指标
主要结局
ICSI outcome and its relation with TSH level
时间窗: 4years
Number of oocyte retrieved , percentage of fertilization rate, cleavage rate, available embryo rate, pregnancy rate analyzed to explore whether serum TSH level in miu/L affect ourtcome or not .
次要结局
未报告次要终点
研究者
Shaimaa Mostafa Mohammed Refaay El shemy
Assistant professor of Obstetrics and Gynecology
Cairo University