Assessment of Autonomic Neuronal Changes During Moderate Rise of Intracranial Pressure in Human
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 3
- 主要终点
- change in sympathetic nerve activity after rise in ICP
研究概览
简要总结
The purpose of this project is to determine during moderate rise of intracranial pressure (ICP) in awake patient, the change in autonomic function and its influence on cerebral and systemic haemodynamics.
详细描述
From preliminary data, we know that changes in ICP influences both systemic and cerebral haemodynamics, introducing the concept of intracranial baroreflex We have to i) confirm the presence of this intracranial baroreflex, ii) analyze the changes in autonomic function during moderate rise in intracranial pressure (ICP) in human, and iii) correlate the changes in cerebral and systemic haemodynamics with autonomic function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient suspect of hydrocephalus with gait problems, urine incontinence and mild cognitive impairment.
- •signed consent
排除标准
- •psychiatric problems
- •severe cognitive decline
研究组 & 干预措施
Hydrocephalus
Patients suffering of hydrocephalus (cognitive impairment, gait disturbance, urinary incontinence and enlargement of the ventricles) require for clinical purpose infusion studies i.e. injection of mock cerebrospinal fluid (CSF) in the sub arachnoid space to artificially increase ICP. We aim at using infusion studies as a indirect tool to assess whether a moderate increase in ICP has any influence on haemodynamics.
干预措施: Infusion (Other)
结局指标
主要结局
change in sympathetic nerve activity after rise in ICP
时间窗: within few minutes
Assessment of autonomic neural function using. 1. microneurography to assess the muscle sympathetic nerve activity 2. measurement of the plasma level changes of noradrenaline 3. power spectral analysis of heart rate and arterial blood pressure
次要结局
- change in hemodynamics after rise in ICP(within few minutes)