Composite Dietary Antioxidant Index and Metabolic Health in Overweight/Obesity in U.S. Adults: Evidence From NHANES: 2003-2020
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Enrollment
- 38,646
- Locations
- 1
- Primary Endpoint
- Overweight/Obesity Assessed by Body Mass Index (BMI)
Study Overview
Brief Summary
This cross-sectional study draws on data from the National Health and Nutrition Examination Survey (NHANES) database. The primary objective is to investigate the associations between the Composite Dietary Antioxidant Index (CDAI) and overweight/obesity, as well as the related metabolic abnormalities, among the U.S. general population. By analyzing this large-scale, nationally representative dataset, the investigators seek to generate evidence that can inform public health policies and clinical practice-ultimately contributing to a deeper understanding of population-level health challenges and the development of targeted strategies to address them.
Study Design
- Study Type
- Observational
- Observational Model
- Ecologic Or Community
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participants with complete data on composite dietary antioxidant index from the NHANES database
- •Participants with complete body mass index (BMI) data from the NHANES database
- •Individuals aged 18 years and older
Exclusion Criteria
- •Participants with missing key data (composite dietary antioxidant index or BMI)
- •Individuals who are pregnant
Arms & Interventions
CDAI Q1 (Lowest Quartile)
Intervention: None (Observational) (Other)
CDAI Q2 (Second Quartile)
Intervention: None (Observational) (Other)
CDAI Q3 (Third Quartile)
Intervention: None (Observational) (Other)
CDAI Q4 (Highest Quartile)
Intervention: None (Observational) (Other)
Outcomes
Primary Outcomes
Overweight/Obesity Assessed by Body Mass Index (BMI)
Time Frame: Baseline: Data collection for calculating BMI occurs during the specific NHANES survey cycle relevant to this study (single - time - point cross - sectional assessment).
Body Mass Index (BMI) will be calculated as weight (in kilograms) divided by the square of height (in meters). According to the World Health Organization's classification, a BMI of 25.0 - 29.9 kg/m² is considered overweight, and a BMI of 30.0 kg/m² or higher is considered obese. Data on weight and height will be obtained from the NHANES dataset.
Metabolic Phenotype Classification (Metabolically Healthy vs. Unhealthy) Assessed by NCEP ATP III Metabolic Syndrome Components
Time Frame: Baseline: Data on metabolic components for phenotype classification will be collected during the corresponding NHANES survey cycle for this study, reflecting a single-time-point cross-sectional assessment.
Metabolic phenotypes are classified as metabolically healthy or unhealthy based on the components of metabolic syndrome defined in the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Waist circumference data is not used in this classification due to its high correlation with BMI. A participant is defined as metabolically healthy if they have none or only one of the following four metabolic abnormalities: (1) Serum triglycerides (TG) ≥ 150 mg/dL; (2) Serum high-density lipoprotein cholesterol (HDL-C) \< 40 mg/dL in men or \< 50 mg/dL in women; (3) Fasting glucose ≥ 100 mg/dL or use of hypoglycemic drugs; (4) Blood pressure ≥ 130/85 mmHg or use of antihypertensive drugs. A participant is defined as metabolically unhealthy if they have two or more of the above metabolic abnormalities. Relevant data will be retrieved from the NHANES database.
Secondary Outcomes
No secondary outcomes reported
Investigators
Jiang Peng
Attending Physician
University-Town Hospital of Chongqing Medical University