The influence of stress on cognitive functioning in Parkinson*s disease

Completed

Conditions: mental processes
Psychological disstress
10029305

Registration Number: NL-OMON37748

Lead Sponsor: Atrium Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 204

Inclusion Criteria

- Parkinson's Disease according to the UKPDS Brain Bank Criteria as diagnosed by a neurologist.
- Stabel dosage of anti-parkinsonian medication at onset of the study

Exclusion Criteria

- Surgical treatment for PD, such as deep brain stimulation.
- Suspected dementia at the onset of the study.
- Presence of co-morbid neurological disorder (e.g. CVA) or infection (e.g. meningitis) within last 5 years other than PD that influences cognitive functioning.
- Medication (e.g. corticosteroid) that influences daily cortisol levels.
- Presence of posttraumatic stress disorder and/or psychotic disorders which influences cognitive functioning.
- Depression according to the Beck Depression Inventory (BDI), cut-off score 15 for PD patients and cut-off score 10 for healthy controls.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Different parameters for stress will be taken into account (cortisol levels,<br /><br>scores on a perceived stress questionnaire). Furthermore, performance on<br /><br>cognitive tasks will be assessed in the PD group and control group. Both groups<br /><br>will be compared with each other. There will be assessed whether:<br /><br>- stress (chronic and acute) influences cognitive functioning in PD<br /><br>- chronic stress is associated with an accelerated cognitive decline in PD<br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Different parameters for stress will be taken into account (induced stress,<br /><br>vulnerability to perceive stress). Furthermore, performance on cognitive tasks<br /><br>as well as medical decision making tasks will be assessed in the PD group and<br /><br>control group. Both groups will be compared with each other. There will be<br /><br>assessed whether:<br /><br>- induced stress influences cognitive functioning in PD<br /><br>- vulnerability to perceive stress moderates the influence of (chronic and<br /><br>acute) stress on cognitive functioning in PD.<br /><br>- cognitive functioning mediates the influence of stress on medical decision<br /><br>making in PD.</p><br>