Comparison of Cerebral Haemodynamics using Transcranial Doppler during Caesarean Delivery under Spinal anaesthesia between Preeclamptic and Normotensive parturients: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- To evaluate changes in cerebral haemodynamics (Middle Cerebral Artery Mean Flow Velocity, Pulsatility Index, Resistance Index, Estimated Cerebral perfusion pressure) in Preeclamptic and Normotensive Parturients under Spinal Anaesthesia.
研究概览
简要总结
This study aims to evaluate changes in cerebral haemodynamics in Preeclamptic and Normotensive Parturients under Spinal Anaesthesia
1.Patient Enrolment Criteria
Inclusion and exclusion criteria applied.
Written informed consent obtained
2.Preoperative Assessment
Demographic data collected.
Indications for cesarean delivery noted.
Preoperative medications recorded.
Laboratory values measured.
Neurological and systemic symptoms documented.
3.ASA Standard Monitors attached
4.Middle Cerebral Artery (MCA) Identification
MCA identified using 2MHz-pulsed TCD probe.
Headframe placed for continuous monitoring.
5.Baseline Measurement
Three measurements taken at 1-minute intervals before anesthesia.
Average score recorded as baseline value.
6.Intraoperative Monitoring
7. Measurements repeated at specified intervals after spinal injection
**8.**Additional reading taken after removal of placenta
9. Parameters monitored continuously until end of operation.
**10.Any significant change
20% from the baseline in any parameters will also be recorded**
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Day(s) 至 45.00 Day(s)（—）
- 性别
- Female
入选标准
- •Normotensive and Preeclamptic parturients with Gestational week 32 and above
- •ASA ( American Society of Anaesthesiologists) physical class II-III
- •Caesarean delivery under Spinal anaesthesia.
排除标准
- •Neurologic, cardiac disease, chronic hypertension, diabetes mellitus or pulmonary disease
- •Urgent category 1 [NICE GUIDELINES ] caesarean delivery due to severe fetal bradycardia, abruptio placenta, cord prolapse or massive haemorrhage, and coagulopathy
- •Patients not willing to participate in the study.
结局指标
主要结局
To evaluate changes in cerebral haemodynamics (Middle Cerebral Artery Mean Flow Velocity, Pulsatility Index, Resistance Index, Estimated Cerebral perfusion pressure) in Preeclamptic and Normotensive Parturients under Spinal Anaesthesia.
时间窗: 6 months
次要结局
- 1.To evaluate 48- hours Post-delivery cerebral haemodynamics .(2.To evaluate correlation between blood pressure and cerebral haemodynamics.)
研究者
Kanishk Arora
All India Institute of Medical Sciences, Bathinda