A Randomized Double-blind Trial of Repetitive Transcranial Magnetic Stimulation in Obsessive -Compulsive Disorder With Three Months Follow-up
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Obsessive Compulsive Disorder
- Sponsor
- University of Brasilia
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Changes in Y-BOCS scale scores relative to baseline
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
This study aimed at verifying whether sessions of repetitive transcranial magnetic stimulation over a certain brain area (the supplementary motor area) could be useful in the relief of Obsessive-Compulsive Disorder symptoms.
Detailed Description
Patients were randomly administered either real (n = 12) or sham (n = 10) rTMS, once a day, 5 days a week, for 2 weeks. Randomization was performed according to a computer-generated schedule. Subjects and scale-rater physician were blind to treatment status of individuals. Only the rTMS administrator was aware of group allocations. Treatment response was assessed by self-and clinician-rated scales before treatment, immediately after treatment and 3 months thereafter, with the same examiner following a subject throughout the study. All patients included in the study had failed adequate pharmacological treatment for at least 2 antiobsessional drugs. Their prescription drugs were continued without change in dosage regimens throughout the study.
Investigators
Joaquim Brasil-Neto
Dr.
University of Brasilia
Eligibility Criteria
Inclusion Criteria
- •age 18 to 60 years
- •diagnosis of obsessive-compulsive disorder (OCD) according to DSM-IV-TR criteria and having OCD of at least moderate severity (YBOCS score of 16 or above).
Exclusion Criteria
- •subjects with comorbid psychiatric disorders (except depression - HAM-D ) or history of drug abuse
- •significant head injury, or of any neurosurgical procedure
- •pregnant women
- •patients with metal implants or illnesses that prevent attendance to sessions
- •patients with a history of seizure or bearing pacemakers
Outcomes
Primary Outcomes
Changes in Y-BOCS scale scores relative to baseline
Time Frame: assessments were at baseline, at 2 weeks and at 3 months
Y-BOCS: Yale-Brown Obsessive-Compulsive Scale