Is treatment with emollients always beneficial? Comparative biophysical and molecularbiological studies of the skinbarrier function in patients with atopic dermatitis, ichtyosis vulgaris and x-linked ichtyosis.
- Conditions
- Patients with Atopic Dermatitis, Ichtyosis vulgaris and X-linked Ichtyosis
- Registration Number
- EUCTR2009-010609-35-SE
- Lead Sponsor
- Department of Medical Sciences, Dermatology and venerology, Uppsala University, Uppsala Sweden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Patients with atopic dermatitis, ichtyosis vulgaris and x-linked ichtyosis. 18-65 yrs of age
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Any other concomittant skin disease. Pregnancy.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To achieve better knowledge about the cause of the impaired skinbarrier function in patients with atopic dermatitis, ichtyosis vulgaris and x-linked ichtyosis. <br>;Secondary Objective: To achieve more knowledge about the effects of emollients on this impaired barrier function, and about which ingredients in emollients that have beneficial or maybe negative effects on the barrier function in these patients.<br>To study if the effects of the different emollients are correlated to the different genotypes in the filaggring gene and a gene coding for steroid sulphatase.<br>;Primary end point(s): To evaluate the effect of 4 weeks daily treatment with emollients on the skin barrier function in patients with impaired barrierfunction.<br> + see E.2.1
- Secondary Outcome Measures
Name Time Method