Comparison of Ropivacaine with Dexmedetomidine versus Ropivacaine with Magnesium Sulfate for Pain Relief After Lumbar Spine Surgery

Not yet recruiting

• Conditions: Other and unspecified cord compression,

• Registration Number: CTRI/2025/04/084862
• Lead Sponsor: SMS Medical College And Hospital

Brief Summary

This study aims to compare the analgesic efficacy of two combinations of medications used for surgical site infiltration in patients undergoing lumbar fixation surgery. Specifically, it will evaluate Ropivacaine combined with Dexmedetomidine versus Ropivacaine combined with Magnesium sulfate. The study will measure postoperative pain relief using Numerical  Rating scale (NRS) scores at various time points, the time to first analgesic request, and total analgesic consumption. Additionally, it will monitor side effects such as hypotension, bradycardia, and nausea. This prospective, randomized, double-blind trial will provide insights into which combination offers superior pain control, potentially improving post-surgical recovery and reducing the need for opioids.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-04-27
• Last Update Posted: 2025-11-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patients willing to give written and informed consent Patients undergoing lumbar spine fixation surgery Patients with ASA physical status 1 or 2.

Exclusion Criteria

Non cooperative patients BMI more than 35kg/m2 History of allergy to any other drugs used during the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To asses and compare mean NRS score at different intervals between the study groups	Just after extubation ,2hours ,6hours ,12hours, 24hours
To assess and compare in mean time of first rescue analgesia intravenous Diclofenac between the study groups	Just after extubation ,2hours ,6hours ,12hours, 24hours
To asses and compare the difference in mean total number of doses of intravenous Diclofenac in 24 hours postoperatively between the study groups	Just after extubation ,2hours ,6hours ,12hours, 24hours

Secondary Outcome Measures

Name	Time	Method
To assess and compare post operative hemodynamic vitals between the study groups	To determine the proportion of patients experiencing side effects between study groups

Trial Locations

Locations (1)

SMS Medical College And Hospital; 🇮🇳 Jaipur, RAJASTHAN, India

SMS Medical College And Hospital

🇮🇳Jaipur, RAJASTHAN, India

Dr Shobha Purohit

Principal investigator

9414050823

Purohit.Shobha@gmail.com