Efficacy and safety of combination 308-nm excimer laser and intralesional corticosteroid versus intralesional corticosteroid monotherapy in the treatment of frontal fibrosing alopecia: a pilot study

Phase 4

Completed

• Conditions: Patient with frontal fibrosing alopecia in active form which can diagnosis by has symptom of itching ,burning,pain,redness,scaling, and pustules or diagnosis by skin biopsy; excimer laser; intralesional corticosteroid; frontal fibrosing alopecia; lichen planopilaris

• Registration Number: TCTR20230816003
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

Brief Summary

The five FFA patients were all female with a mean age of 56.2 years. The average disease duration was 6.4 years. The respective FFASI scores for combination and monotherapy groups were 29.6 vs. 30.0 at baseline and 29.2 vs.29.6 at week 16. Two patients has minimal improvement on both sides of the scalp at week 16. Three patients reported no improvement on either side of the scalp,whereas two patients reported mild to moderate improvements with no difference between both sides of the scalp.

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-01-05
• Study Start: 2023-08-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

1. Age older than 18 years old
2. Patient with frontal fibrosing alopecia in active form which can diagnosis by has symptom of itching ,burning,pain,redness,scaling, and pustules or diagnosis by skin biopsy
3. Patient didn't have any treatment about 1 month before joining the project
4. No pregnancy

Exclusion Criteria

1. Patients which has wound or inflammation at scalp
2. Patients that don't want to join the project

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of Frontal fibrosing alopecia baseline, 12 week after first treatment FFASI index

Secondary Outcome Measures

Name	Time	Method
photograph baseline, 4 weeks after first treatment, 8 weeks after first treatment, 12 weeks after first treatment, 4 weeks after last treatment Canon,Clinician assessment baseline, 4 weeks after first treatment, 8 weeks after first treatment, 12 weeks after first treatment, 4 weeks after last treatment global improvement score,Safety 4 weeks after first treatment, 8 weeks after first treatment, 12 weeks after first treatment, 4 weeks after last treatment Adverse events,Patient satisfication 4 weeks after first treatment, 8 weeks after first treatment, 12 weeks after first treatment, 4 weeks after last treatment VAS