Influence of Different Anesthetic Procedures on Sleep Disorder Breathing

Completed

• Conditions: Obstructive Sleep Apnea
• Interventions: Procedure: anesthesia

• Registration Number: NCT03499132
• Lead Sponsor: St. Anne's University Hospital Brno, Czech Republic

Brief Summary

Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications. These complications are caused not only by the OSA itself, but also by exacerbations of this syndrome during the perioperative period (1). Benzodiazepines, volatile anesthetics and opioids may lead to lower hypoxia and hypercapnia sensitivity and may cause respiratory depression (2-5). Therefore, preference of neuraxial blockades and avoidance of opioids has been suggested for patients with OSA (6). However, there is still lack of evidence to evaluate the effects of various anesthesia procedures on OSA (6,7). We hypothesize different anesthetic procedures will have different effect on OSA exacerbations in the postoperative period. Accordingly, the aim of this study is to compare the number of sleep disordered breathing episodes in the postoperative period in patients with different anesthetic procedures.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-01
• Study First Submitted: 2018-04-08
• Study First Submitted QC: 2018-04-08
• Study First Posted: 2018-04-17
• Primary Completion: 2019-12-31
• Status Verified: 2020-03
• Study Completion: 2020-03-01
• Last Update Submitted: 2020-03-16
• Last Update Posted: 2020-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• elective orthopedic surgery

Exclusion Criteria

• already diagnosed sleep disorder breathing
• continuous positive airway pressure therapy
• tracheostomy
• American Society of Anesthesiologists class IV-V

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Subarachnoid anesthesia (with opioids)	anesthesia	orthopedic surgery plus subarachnoid anesthesia (plus intrathecal opioid)
Regional anesthesia (without opioids)	anesthesia	orthopedic surgery plus regional anesthesia (peripheral nerve block, continous or single shot, without opioid use)
General anesthesia (with opioids)	anesthesia	orthopedic surgery plus general anesthesia
Epidural anesthesia (without opioids)	anesthesia	orthopedic surgery plus epidural anesthesia (without opioids use)

Primary Outcome Measures

Name	Time	Method
Apnea-hypopnea index change	4 nights after surgery	Changes (post-pre) in apnea-hypopnea index 4 nights post surgery

Trial Locations

Locations (1)

St. Anne's University Hospital Brno; 🇨🇿 Brno, Czech Republic, Czechia