Influence of Different Anesthetic Procedures on Sleep Disorder Breathing in Adult Patients Undergoing Elective Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obstructive Sleep Apnea
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Apnea-hypopnea index change
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications. These complications are caused not only by the OSA itself, but also by exacerbations of this syndrome during the perioperative period (1). Benzodiazepines, volatile anesthetics and opioids may lead to lower hypoxia and hypercapnia sensitivity and may cause respiratory depression (2-5). Therefore, preference of neuraxial blockades and avoidance of opioids has been suggested for patients with OSA (6). However, there is still lack of evidence to evaluate the effects of various anesthesia procedures on OSA (6,7). We hypothesize different anesthetic procedures will have different effect on OSA exacerbations in the postoperative period. Accordingly, the aim of this study is to compare the number of sleep disordered breathing episodes in the postoperative period in patients with different anesthetic procedures.
Investigators
Ivan Cundrle
M.D., Ph.D.
St. Anne's University Hospital Brno, Czech Republic
Eligibility Criteria
Inclusion Criteria
- •elective orthopedic surgery
Exclusion Criteria
- •already diagnosed sleep disorder breathing
- •continuous positive airway pressure therapy
- •tracheostomy
- •American Society of Anesthesiologists class IV-V
Outcomes
Primary Outcomes
Apnea-hypopnea index change
Time Frame: 4 nights after surgery
Changes (post-pre) in apnea-hypopnea index 4 nights post surgery