Skip to main content
Clinical Trials/NCT03499132
NCT03499132
Completed
Not Applicable

Influence of Different Anesthetic Procedures on Sleep Disorder Breathing in Adult Patients Undergoing Elective Surgery

St. Anne's University Hospital Brno, Czech Republic1 site in 1 country90 target enrollmentMarch 1, 2018

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Obstructive Sleep Apnea
Sponsor
St. Anne's University Hospital Brno, Czech Republic
Enrollment
90
Locations
1
Primary Endpoint
Apnea-hypopnea index change
Status
Completed
Last Updated
6 years ago

Overview

Brief Summary

Obstructive sleep apnea (OSA) is a common form of sleep disordered breathing characterized by partial or complete upper airway obstructions during sleep. OSA is associated with major comorbidities and perioperative complications. These complications are caused not only by the OSA itself, but also by exacerbations of this syndrome during the perioperative period (1). Benzodiazepines, volatile anesthetics and opioids may lead to lower hypoxia and hypercapnia sensitivity and may cause respiratory depression (2-5). Therefore, preference of neuraxial blockades and avoidance of opioids has been suggested for patients with OSA (6). However, there is still lack of evidence to evaluate the effects of various anesthesia procedures on OSA (6,7). We hypothesize different anesthetic procedures will have different effect on OSA exacerbations in the postoperative period. Accordingly, the aim of this study is to compare the number of sleep disordered breathing episodes in the postoperative period in patients with different anesthetic procedures.

Registry
clinicaltrials.gov
Start Date
March 1, 2018
End Date
March 1, 2020
Last Updated
6 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
St. Anne's University Hospital Brno, Czech Republic
Responsible Party
Principal Investigator
Principal Investigator

Ivan Cundrle

M.D., Ph.D.

St. Anne's University Hospital Brno, Czech Republic

Eligibility Criteria

Inclusion Criteria

  • elective orthopedic surgery

Exclusion Criteria

  • already diagnosed sleep disorder breathing
  • continuous positive airway pressure therapy
  • tracheostomy
  • American Society of Anesthesiologists class IV-V

Outcomes

Primary Outcomes

Apnea-hypopnea index change

Time Frame: 4 nights after surgery

Changes (post-pre) in apnea-hypopnea index 4 nights post surgery

Study Sites (1)

Loading locations...

Similar Trials