Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Lung Volume Initiation
研究概览
简要总结
Cough is a defensive behavior that involves three stages. A large inspiratory phase, a compression phase where the vocal folds close and subglottal pressure is developed, and an expiratory phase. Cough serves to protect the upper and lower airways from material such as liquids, solids, or saliva, that have been aspirated. There are two types of cough: voluntary and reflex cough. Voluntary cough involves a cough to command. Reflex cough is a cough that is generated secondary to a stimulus in or near the airway. There has been some research regarding the differences between voluntary and reflex cough. However, no research has described the differences in airflow or movement pattern (kinematics) between the two types of cough. This study seeks to determine the respiratory kinematics and airflow differences between voluntary and reflex cough in healthy participants.
详细描述
As a participant, completion of this study will require the following:
Investigators will first place cotton elastic bands around your chest and abdomen so that measures of chest wall and abdominal movements can be measured. Then, tests of your breathing made from pulmonary function testing will be completed.
Investigators will then have you complete a maximum inspiration followed by a maximum expiration three times.
Investigators will ask you to produce a voluntary cough three times into a facemask which is attached to a computer.
Then the investigators will provide you with nebulized water (FOG) through the facemask for up to a minute three times. You will have a minute break in between each presentation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults between the ages of 18-80 years.
- •Ability to provide informed consent.
排除标准
- •No history of smoking within the last 5 years as this reduces the sensitivity to capsaicin
- •No history of neurological disease (i.e. Parkinson's disease, stroke, traumatic brain injury, etc.)
- •No known allergy to capsaicin
- •No history of respiratory disease (i.e. asthma, chronic obstructive pulmonary disease, or respiratory infection within the last 5 weeks.)
研究组 & 干预措施
Healthy adults who receive capsaicin
Single treatment consisting of healthy adults.
干预措施: Healthy adults who receive capsaicin (Drug)
结局指标
主要结局
Lung Volume Initiation
时间窗: 1 hour
Respiratory kinematic measure: lung volume initiation (LVI) Lung volume initiation is a measure of the volume of air in the lungs prior to a respiratory task.
次要结局
- Peak Expiratory Airflow Rate(1 hour)
- Urge-to-cough(1 hour)